Evaluation of immune response to single dose of quadrivalent HPV vaccine at 10-year post-vaccination.

ABSTRACT:

Background

The recent World Health Organization recommendation supporting single-dose of HPV vaccine will significantly reduce programmatic cost, mitigate the supply shortage, and simplify logistics, thus allowing more low- and middle-income countries to introduce the vaccine. From a programmatic perspective the durability of protection offered by a single-dose will be a key consideration. The primary objectives of the present study were to determine whether recipients of a single-dose of quadrivalent HPV vaccine had sustained immune response against targeted HPV types (HPV 6,11,16,18) at 10 years post-vaccination and whether this response was superior to the natural antibody titres observed in unvaccinated women.

Methods

Participants received at age 10-18 years either one,

SUBMITTER: Joshi S 

PROVIDER: S-EPMC9792650 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature