Ontology highlight
ABSTRACT:
SUBMITTER: Kanatsu-Shinohara M
PROVIDER: S-EPMC9792657 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Kanatsu-Shinohara Mito M Lee Jiyoung J Miyazaki Takehiro T Morimoto Hiroko H Shinohara Takashi T
The Journal of reproduction and development 20221013 6
Oogenesis depends on close interactions between oocytes and granulosa cells. Abnormal signaling between these cell types can result in infertility. However, attempts to manipulate oocyte-granulosa cell interactions have had limited success, likely due to the blood-follicle barrier (BFB), which prevents the penetration of exogenous materials into ovarian follicles. Here, we used adenoviruses (AVs) to manipulate the oocyte-granulosa cell interactions. AVs penetrated the BFB and transduced granulos ...[more]