Identification and validation of senescence-related genes in circulating endothelial cells of patients with acute myocardial infarction.

ABSTRACT:

Background

Acute myocardial infarction (AMI) is the main clinical cause of death and cardiovascular disease and thus has high rates of morbidity and mortality. The increase in cardiovascular disease with aging is partly the result of vascular endothelial cell senescence and associated vascular dysfunction. This study was performed to identify potential key cellular senescence-related genes (SRGs) as biomarkers for the diagnosis of AMI using bioinformatics.

Methods

Using the CellAge database, we identified cellular SRGs. GSE66360 and GSE48060 for AMI patients and healthy controls and GSE19322 for mice were downloaded from the Gene Expression Omnibus (GEO) database. The GSE66360 dataset was divided into a training set and a validation set. The GSE48060 dataset was used as anot

SUBMITTER: Xiang J 

PROVIDER: S-EPMC9792765 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature