Assessment of causal associations between uric acid and 25-hydroxyvitamin D levels.

ABSTRACT:

Background

Previous observational studies have revealed the association between serum uric acid and 25-hydroxyvitamin D. However, the causality and the direction of the associations remain unknown. Thus, we performed a two-sample bidirectional Mendelian Randomization (MR) analysis to investigate the causal association between uric acid and 25-hydroxyvitamin D and to determine the direction of the association.

Method

Based on the summary-level GWAS data from large genome-wide association studies, several steps were taken in our analysis to select eligible single-nucleotide polymorphisms (SNPs), which were strongly related to exposure as the instrumental variables. We used different analytical methods, such as inverse-variance weighting (IVW) method, weighted median, MR-Egger

SUBMITTER: Han Y 

PROVIDER: S-EPMC9792848 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature