Vitamin D pathway gene variation rs3740165 is associated with serological uric acid levels in healthy Chinese women.

ABSTRACT:

Aim

To investigate the relationship between gene polymorphisms involved in the vitamin D metabolic pathway and serum uric acid (UA) levels in Chinese women.

Methods

Fifteen key genes within the vitamin D metabolic pathway were screened using 96 single nucleotide polymorphisms in a group of 1,206 (37.96 ± 13.08 years) unrelated healthy Chinese women (aged 20-85 years). Blood and urine tests were performed at the same time. The Wilcoxon Mann-Whitney test was used to compare groups aged ≤50 years and >50 years. The mean serum UA values were computed within each group of homozygous referent, heterozygous, and homozygous variant genotypes for each single nucleotide polymorphism.

Results

The exclusion process left 1,169 participants (38.16 ± 13.13 years) for analysis. One s

SUBMITTER: Gu J 

PROVIDER: S-EPMC9792855 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature