Accelerated ageing is associated with increased COVID-19 severity and differences across ethnic groups may exist.

ABSTRACT:

Background

While increased age is an established risk factor for COVID-19, there is great heterogeneity in outcomes within age groups. This is because chronological age does not reflect health, unlike biological age. We intend to investigate the association between accelerated ageing and COVID-19 outcomes through the lens of three measures, namely phenotypic age acceleration (PhenoAgeAccel), telomere length (Adjusted T/S Ratio) and facial ageing, and to examine whether there are differences across ethnic groups.

Methods

Taking participants from the UK Biobank, we associated accelerated ageing with severe COVID-19 outcomes, defined as COVID-related hospitalisation or death. Separate logistic regressions models were created for age and the three accelerated ageing-related vari

SUBMITTER: Reeves J 

PROVIDER: S-EPMC9792858 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature