Principles of medical and oncological management of giant masses of the mediastinum: a narrative review.

ABSTRACT:

Background and objective

Giant mediastinal tumors are represented by well-defined histological variants originating from different structures and compartments while their clinical presentation may be similar and characterized by the same set of symptoms, the well-known mediastinal syndrome (MS). In 80% of cases the MS is caused by malignant neoplasms, such as lung tumors, in 10-18% of cases by hematological neoplasms and in 2-3% by benign causes. In this review we investigated the medical treatment of main giant mediastinal tumors, focusing our interest on the objective response rate (ORR), as it represents the most suitable parameter to predict the volumetric reduction of the neoplasm and, consequently, the regression of their most severe complication, the MS. We will also cover t

SUBMITTER: Conci N 

PROVIDER: S-EPMC9792870 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature