Impact of broad-spectrum antibiotics on the gut-microbiota-spleen-brain axis.

ABSTRACT: The spleen is a key immune-related organ that plays a role in communication between the brain and the immune system through the brain-spleen axis and brain-gut-microbiota axis. However, how the gut microbiota affects spleen and brain function remains unclear. Here, we investigated whether microbiome depletion induced by administration of an antibiotic cocktail (ABX) affects spleen and brain function. Treatment with ABX for 14 days resulted in a significant decrease in spleen weight and significant alterations in splenic functions, including the percentage of neutrophils, NK cells, macrophages, and CD8⁺ T cells. Furthermore, ABX treatment resulted in the depletion of a large portion of the gut microbiota. Untargeted metabolomics analysis showed that ABX treatment caused alteratio

SUBMITTER: Wan X 

PROVIDER: S-EPMC9793168 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature