Clinicopathological and immunological profiles of prostate adenocarcinoma and neuroendocrine prostate cancer.

ABSTRACT:

Background

Biomarkers of DNA damage repair deficiency provide opportunities for personalized treatment with immunotherapy. However, there is limited research on the immune microenvironment of adeno-neuroendocrine prostate cancer (NEPC). In this study, we aimed to assess and describe the comprehensive clinicopathological manifestations of NEPC to improve diagnosis and predict prognosis.

Methods

A retrospective medical record review of 66 patients with prostate cancer (PCa) was performed. PCa samples from the 66 patients were analyzed using immunohistochemical staining for the detection of chromogranin, neural cell adhesion molecule 1, and synaptophysin. For tumor-associated immune microenvironment analysis, PD-L1, CD3, and CD8 were labeled in tissue slides. The effect of clin

SUBMITTER: Huang G 

PROVIDER: S-EPMC9793563 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature