BDNF exon IV promoter methylation and antidepressant action: a complex interplay.

ABSTRACT:

Background

BDNF exon IV promoter methylation is a potential biomarker for treatment response to antidepressants in MDD. We have previously shown CpG-87 methylation as a successful biomarker for the prediction of non-response to monoaminergic antidepressants like the SSRI Fluoxetine or the SNRI Venlafaxine. This study aimed to dissect the biological evidence and mechanisms for the functionality of CpG-87 methylation in a cell culture model.

Results

We observed a significant interaction between methylation and antidepressant-mediated transcriptional activity in BDNF exon IV promoter. In addition, antidepressant treatment increased the promoter methylation in a concentration-dependent manner. Further single CpG methylation of -87 did not change the promoter activity, but methyl

SUBMITTER: Pathak H 

PROVIDER: S-EPMC9793565 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature