A comparison of marker-based estimators of inbreeding and inbreeding depression.

ABSTRACT:

Background

The availability of genome-wide marker data allows estimation of inbreeding coefficients (F, the probability of identity-by-descent, IBD) and, in turn, estimation of the rate of inbreeding depression (ΔID). We investigated, by computer simulations, the accuracy of the most popular estimators of inbreeding based on molecular markers when computing F and ΔID in populations under random mating, equalization of parental contributions, and artificially selected populations. We assessed estimators described by Li and Horvitz (F_LH1 and F_LH2), VanRaden (F_VR1 and F_VR2), Yang and colleagues (F_YA1 and F_YA2), marker homozygosity (F_HOM), runs of homozygosity (F_ROH) and estimates based on pedigree

SUBMITTER: Caballero A 

PROVIDER: S-EPMC9793638 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature