Mendelian randomization analyses in ocular disease: a powerful approach to causal inference with human genetic data.

ABSTRACT: Ophthalmic epidemiology is concerned with the prevalence, distribution and other factors relating to human eye disease. While observational studies cannot avoid confounding factors from interventions, human eye composition and structure are unique, thus, eye disease pathogenesis, which greatly impairs quality of life and visual health, remains to be fully explored. Notwithstanding, inheritance has had a vital role in ophthalmic disease. Mendelian randomization (MR) is an emerging method that uses genetic variations as instrumental variables (IVs) to avoid confounders and reverse causality issues; it reveals causal relationships between exposure and a range of eyes disorders. Thus far, many MR studies have identified potentially causal associations between lifestyles or biological exposures

SUBMITTER: Li J 

PROVIDER: S-EPMC9793675 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature