A high-fat diet has sex-specific effects on nicotine vapor self-administration in mice.

ABSTRACT:

Background

Previous investigations have shown that fat-rich diets increase vulnerability to drug dependence, including nicotine. Despite this knowledge, few investigations into the neurochemical mechanisms have been completed. Our objective here was to examine if high-fat diet (HFD) impacted nicotine intake and in parallel examine potential changes in dopamine signaling.

Methods

Adult male and female C57/BL6J mice were used in nicotine e-vape® self-administration (EVSA) assays after being maintained on a standard diet or HFD for 6 weeks. In a separate cohort of mice, dopamine release in the nucleus accumbens core was examined with fast-scan cyclic voltammetry.

Results

Female mice assigned to HFD exhibited increased nicotine EVSA during low-effort responding (FR1) when

SUBMITTER: Henderson BJ 

PROVIDER: S-EPMC9793688 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature