Circulating messenger RNA variants as a potential biomarker for surveillance of hepatocellular carcinoma.

ABSTRACT:

Background and rationale

Liver derived messenger ribonucleic acid (mRNA) transcripts were reported to be elevated in the circulation of hepatocellular carcinoma (HCC) patients. We now report the detection of high-risk mRNA variants exclusively in the circulation of HCC patients. Numerous genomic alleles such as single nucleotide polymorphisms (SNPs), nucleotide insertions and deletions (called Indels), splicing variants in many genes, have been associated with elevated risk of cancer. Our findings potentially offer a novel non-invasive platform for HCC surveillance and early detection.

Approach

RNAseq analysis was carried out in the plasma of 14 individuals with a diagnosis of HCC, 8 with LC and no HCC, and 6 with no liver disease diagnosis. RNA from 6 matching tumors and 5

SUBMITTER: Block T 

PROVIDER: S-EPMC9793749 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature