Ontology highlight
ABSTRACT:
SUBMITTER: Nandi A
PROVIDER: S-EPMC9793758 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Nandi Anirban A Chartrand Thomas T Van Geit Werner W Buchin Anatoly A Yao Zizhen Z Lee Soo Yeun SY Wei Yina Y Kalmbach Brian B Lee Brian B Lein Ed E Berg Jim J Sümbül Uygar U Koch Christof C Tasic Bosiljka B Anastassiou Costas A CA
Cell reports 20220801 6
Which cell types constitute brain circuits is a fundamental question, but establishing the correspondence across cellular data modalities is challenging. Bio-realistic models allow probing cause-and-effect and linking seemingly disparate modalities. Here, we introduce a computational optimization workflow to generate 9,200 single-neuron models with active conductances. These models are based on 230 in vitro electrophysiological experiments followed by morphological reconstruction from the mouse ...[more]