Combinatorial Polyacrylamide Hydrogels for Preventing Biofouling on Implantable Biosensors.

ABSTRACT: Biofouling on the surface of implanted medical devices and biosensors severely hinders device functionality and drastically shortens device lifetime. Poly(ethylene glycol) and zwitterionic polymers are currently considered "gold-standard" device coatings to reduce biofouling. To discover novel anti-biofouling materials, a combinatorial library of polyacrylamide-based copolymer hydrogels is created, and their ability is screened to prevent fouling from serum and platelet-rich plasma in a high-throughput parallel assay. It is found that certain nonintuitive copolymer compositions exhibit superior anti-biofouling properties over current gold-standard materials, and machine learning is used to identify key molecular features underpinning their performance. For validation, the surfaces of elect

SUBMITTER: Chan D 

PROVIDER: S-EPMC9793805 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature