Targeted capture enrichment and sequencing identifies HLA variants associated with the severity of COVID-19.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19) is currently a global pandemic. The pathogenesis of severe COVID-19 has been widely investigated, but it is still unclear. Human leukocyte antigen (HLA) plays a central role in immune response, and its variants might be related to COVID-19 progression and severity.

Objective

To investigate the hypothesis that individual HLA variations could alter the course of COVID-19 and might be associated with the severity of COVID-19.

Methods

In this study, we conducted an HLA targeted capture enrichment and sequencing of severe COVID-19 patients matched to mild cases. A total of 16 COVID-19 patients, confirmed by SARS-CoV-2 viral RNA polymerase-chain-reaction (PCR) test and chest computed tomography (CT) scan, were enrolled in this

SUBMITTER: Liu C 

PROVIDER: S-EPMC9793816 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature