Probing neural codes with two-photon holographic optogenetics.

ABSTRACT: Optogenetics ushered in a revolution in how neuroscientists interrogate brain function. Because of technical limitations, the majority of optogenetic studies have used low spatial resolution activation schemes that limit the types of perturbations that can be made. However, neural activity manipulations at finer spatial scales are likely to be important to more fully understand neural computation. Spatially precise multiphoton holographic optogenetics promises to address this challenge and opens up many new classes of experiments that were not previously possible. More specifically, by offering the ability to recreate extremely specific neural activity patterns in both space and time in functionally defined ensembles of neurons, multiphoton holographic optogenetics could allow neuroscienti

SUBMITTER: Adesnik H 

PROVIDER: S-EPMC9793863 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature