Network pharmacology approach and experimental verification of Dan-Shen Decoction in the treatment of ischemic heart disease.

ABSTRACT:

Context

Dan-Shen Decoction, which is composed of Danshen, Tanxiang and Sharen, has a good therapeutic effect on ischemic heart disease (IHD). However, systematic research on the exact mechanism of action of Dan-Shen Decoction is still lacking. The anti-IHD effect of Dan-Shen Decoction was examined in this study using a systematic pharmacological method.

Objective

This study validates the efficacy and explores the potential mechanisms of Dan-Shen Decoction in treating IHD by integrating network pharmacology analyses and experimental verification.

Materials and methods

The active components, critical targets and potential mechanisms of Dan-Shen Decoction against IHD were predicted by network pharmacology and molecule docking. H9c2 cells were pretreated with various 1 µg

SUBMITTER: Gong D 

PROVIDER: S-EPMC9793910 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature