Ribonuclease T2 represents a distinct circularly permutated version of the BECR RNases.

ABSTRACT: Detection of homologous relationships among proteins and understanding their mechanisms of diversification are major topics in the fields of protein science, bioinformatics, and phylogenetics. Recent developments in sequence/profile-based and structural similarity-based methods have greatly facilitated the unification and classification of many protein families into superfamilies or folds, yet many proteins remain unclassified in current protein databases. As one of the three earliest identified RNases in biology, ribonuclease T2, also known as RNase I in Escherichia coli, RNase Rh in fungi, or S-RNase in plant, is thought to be an ancient RNase family due to its widespread distribution and distinct structure. In this study, we present evidence that RNase T2 represents a circularly permuta

SUBMITTER: Li H 

PROVIDER: S-EPMC9793965 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature