Clinical, histopathologic, immunohistochemical, and electron microscopic findings in cutaneous monkeypox: A multicenter retrospective case series in Spain.

ABSTRACT:

Background

The worldwide outbreak of monkeypox has evidenced the usefulness of the dermatologic manifestations for its diagnosis.

Objective

To describe the histopathologic and immunohistochemical findings of monkeypox cutaneous lesions.

Methods

This is a retrospective histopathologic and immunohistochemical study of 20 patients with positive Monkeypox virus DNA polymerase chain reaction and immunohistochemical positivity for Vaccinia virus in cutaneous lesions. Four cases were also examined by electron microscopy.

Results

The most characteristic histopathologic findings consisted of full-thickness epidermal necrosis with hyperplasia and keratinocytic ballooning at the edges. In some cases, the outer root sheath of the hair follicle and the sebaceous gland epith

SUBMITTER: Rodriguez-Cuadrado FJ 

PROVIDER: S-EPMC9794029 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature