Association of zinc deficiency with infectious complications in pediatric hematopoietic stem cell transplantation patients.

ABSTRACT:

Background

Zinc plays essential roles in immune function and epithelial integrity. Patients undergoing hematopoietic stem cell transplantation (HSCT) often have low plasma zinc levels because of poor intake and diarrhea. We hypothesized that patients with zinc deficiency before HSCT had worse infectious complications after HSCT compared with patients with normal zinc levels. Citrulline, a marker of intestinal integrity, was also hypothesized to be lower in patients with zinc deficiency.

Patients and methods

Thirty patients undergoing HSCT at Ramathibodi Hospital during March 2020-September 2021 were enrolled. Blood samples for plasma zinc and citrulline were collected during the HSCT period. The 14- and 90-day outcomes after HSCT were prospectively recorded.

Results

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SUBMITTER: Suwanphoerung W 

PROVIDER: S-EPMC9794056 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature