Quadratic relationship between systolic blood pressure and white matter lesions in individuals with hypertension.

ABSTRACT:

Background

There is a well documented relationship between cardiovascular risk factors and the development of brain injury, which can lead to cognitive dysfunction. Hypertension (HTN) is a condition increasing the risk of silent and symptomatic ischemic brain lesions. Although benefits of hypertension treatment are indisputable, the target blood pressure value where the possibility of tissue damage is most reduced remains under debate.

Method

Our group performed a cross-sectional ( n  = 376) and longitudinal ( n  = 188) study of individuals without dementia or stroke (60% women n  = 228, age 68.5 ± 7.4 years; men n  = 148, age 70.7 ± 6.9 years). Participants were split into hypertensive ( n  = 169) and normotensive ( n  = 207) groups. MR images were obtained on a 3T system.

SUBMITTER: Woldstad C 

PROVIDER: S-EPMC9794123 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature