Anti-Epileptic Drug Target Perturbation and Intracranial Aneurysm Risk: Mendelian Randomization and Colocalization Study.

ABSTRACT:

Background

In a genome-wide association study of intracranial aneurysms (IA), enrichment was found between genes associated with IA and genes encoding targets of effective anti-epileptic drugs. Our aim was to assess if this pleiotropy is driven by shared disease mechanisms that could potentially highlight a treatment strategy for IA.

Methods

Using 2-sample inverse-variance weighted Mendelian randomization and genetic colocalization analyses we assessed: (1) if epilepsy liability in general affects IA risk, and (2) whether changes in gene- and protein-expression levels of anti-epileptic drug targets in blood and arterial tissue may causally affect IA risk.

Results

We found no overall effect of epilepsy liability on IA. Expression of 21 genes and 13 proteins correspondi

SUBMITTER: Bakker MK 

PROVIDER: S-EPMC9794136 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature