Prognostic and therapeutic implication of m6A methylation in Crohn disease.

ABSTRACT:

Background

N6-methyladenosine (m6A) methylation has been reported to participate in inflammatory bowel disease (including Crohn disease [CD]). However, the prognostic and therapeutic implication of m6A methylation modification in CD is still unclear.

Methods

Genomic information of CD patients was integrated to assess disease-related m6A regulators, and difference and correlation analyses of m6A regulators were explored by using the R packages. Next, CD patients were classified by the expression of differential and intersecting genes in m6A regulators, and difference and correlation analyses were conducted among immune infiltration and therapeutic responses. Finally, colon tissue resected from patients with CD were assessed to verify expression of Wilms tumor 1-associated pro

SUBMITTER: He Y 

PROVIDER: S-EPMC9794314 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature