Construction of molecular subgroups in childhood systemic lupus erythematosus using bioinformatics.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder. In patients with childhood SLE (cSLE), the onset of the disease occurs before 18 years of age and accounts for a high proportion of childhood autoimmune diseases. Adult SLE and cSLE differ in terms of clinical manifestations, gene expression profiles, and treatment. Because current diagnostic methods do not meet clinical requirements, researchers currently use transcriptome analysis to investigate the characteristics of the cSLE genome. In the present study, we used bioinformatics methods to genotype cSLE and identify potential therapeutic targets.

Methods

The transcriptomes of 952 patients with cSLE and 94 normal controls were obtained from the Gene Expression Omnibus using unsupervised class le

SUBMITTER: Ma J 

PROVIDER: S-EPMC9794347 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature