Current Trends and Approaches to the Search for Genetic Determinants of Aging and Longevity.

ABSTRACT: Aging is a natural process of extinction of the body and the main aspect that determines the life expectancy for individuals who have survived to the post-reproductive period. The process of aging is accompanied by certain physiological, immune, and metabolic changes in the body, as well as the development of age-related diseases. The contribution of genetic factors to human life expectancy is estimated at about 25-30%. Despite the success in identifying genes and metabolic pathways that may be involved in the life extension process in model organisms, the key question remains to what extent these data can be extrapolated to humans, for example, because of the complexity of its biological and sociocultural systems, as well as possible species differences in life expectancy and causes of mo

SUBMITTER: Kunizheva SS 

PROVIDER: S-EPMC9794410 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature