Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury.
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ABSTRACT:
SUBMITTER: Van Steenbergen V
PROVIDER: S-EPMC9794600 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
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Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury.
Van Steenbergen Valérie V Burattini Laura L Trumpp Michelle M Fourneau Julie J Aljović Almir A Chahin Maryam M Oh Hanseul H D'Ambra Marta M Bareyre Florence M FM
The Journal of experimental medicine 20221226 3
Functional recovery after incomplete spinal cord injury depends on the effective rewiring of neuronal circuits. Here, we show that selective chemogenetic activation of either corticospinal projection neurons or intraspinal relay neurons alone led to anatomically restricted plasticity and little functional recovery. In contrast, coordinated stimulation of both supraspinal centers and spinal relay stations resulted in marked and circuit-specific enhancement of neuronal rewiring, shortened EMG late ...[more]
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2021-05-01 | GSE171441 | GEO