4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer.

ABSTRACT: Nutrient-limiting conditions are common during cancer development. The coordination of cellular glucose levels and cell survival is a fundamental question in cell biology and has not been completely understood. 4EBP1 is known as a translational repressor to regulate cell proliferation and survival by controlling translation initiation, however, whether 4EBP1 could participate in tumor survival by other mechanism except for translational repression function, especially under glucose starvation conditions remains unknown. Here, we found that protein levels of 4EBP1 was up-regulated in the central region of the tumor which always suffered nutrient deprivation compared with the peripheral region. We further discovered that 4EBP1 was dephosphorylated by PTPMT1 under glucose starvation condition

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9794714 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature