Multimodal and multidomain lesion network mapping enhances prediction of sensorimotor behavior in stroke patients.

ABSTRACT: Beyond the characteristics of a brain lesion, such as its etiology, size or location, lesion network mapping (LNM) has shown that similar symptoms after a lesion reflects similar dis-connectivity patterns, thereby linking symptoms to brain networks. Here, we extend LNM by using a multimodal strategy, combining functional and structural networks from 1000 healthy participants in the Human Connectome Project. We apply multimodal LNM to a cohort of 54 stroke patients with the aim of predicting sensorimotor behavior, as assessed through a combination of motor and sensory tests. Results are two-fold. First, multimodal LNM reveals that the functional modality contributes more than the structural one in the prediction of sensorimotor behavior. Second, when looking at each modality individually, t

SUBMITTER: Jimenez-Marin A 

PROVIDER: S-EPMC9794717 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature