Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment in male mice.

ABSTRACT: Estrogen receptor alpha (ERα) signaling has beneficial skeletal effects in males. ERα signaling also affects other tissues, and to find bone-specific treatments, more knowledge regarding tissue-specific ERα signaling is needed. ERα is subjected to posttranslational modifications, including phosphorylation, which can influence ERα function in a tissue-specific manner. To determine the importance of phosphorylation site S122 (corresponding to human ERα site S118) for the skeleton and other tissues, male mice with a S122A mutation were used. Total areal bone mineral density was similar between gonadal intact S122A and WT littermates followed up to 12 months of age, and weights of estrogen-responsive organs normalized for body weight were unchanged between S122A and WT males at both 3 and 12 m

SUBMITTER: Horkeby K 

PROVIDER: S-EPMC9794719 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature