A knowledge integration strategy for the selection of a robust multi-stress biomarkers panel for Bacillus subtilis.

ABSTRACT: One challenge in the engineering of biological systems is to be able to recognise the cellular stress states of bacterial hosts, as these stress states can lead to suboptimal growth and lower yields of target products. To enable the design of genetic circuits for reporting or mitigating the stress states, it is important to identify a relatively reduced set of gene biomarkers that can reliably indicate relevant cellular growth states in bacteria. Recent advances in high-throughput omics technologies have enhanced the identification of molecular biomarkers specific states in bacteria, motivating computational methods that can identify robust biomarkers for experimental characterisation and verification. Focused on identifying gene expression biomarkers to sense various stress states in B

SUBMITTER: Huang Y 

PROVIDER: S-EPMC9794971 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature