Class of hemorrhagic shock is associated with progressive diastolic coronary flow reversal and diminished left ventricular function.

ABSTRACT: Introduction: The relationship between coronary artery flow and left ventricular (LV) function during hemorrhagic shock remains unknown. The aim of this study was to quantify coronary artery flow directionality alongside left ventricular function through the four classes of hemorrhage shock. Methods: Following baseline data collection, swine were exsanguinated into cardiac arrest via the femoral artery using a logarithmic bleed, taking each animal through the four classes of hemorrhagic shock based on percent bleed (class I: 15%; class II: 15%-30%; class III: 30%-40%; class IV: >40%). Telemetry data, left ventricular pressure-volume loops, and left anterior descending artery flow tracings over numerous cardiac cycles were collected and analyzed for each animal througho

SUBMITTER: Elansary NN 

PROVIDER: S-EPMC9795012 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature