Genetic characterization of juvenile sudden cardiac arrest and death in Tuscany: The ToRSADE registry.

ABSTRACT:

Background

Sudden cardiac arrest (SCA) in young people represents a dramatic event, often leading to severe neurologic outcomes or sudden cardiac death (SCD), and is frequently caused by genetic heart diseases. In this study, we report the results of the Tuscany registry of sudden cardiac death (ToRSADE) registry, aimed at monitoring the incidence and investigating the genetic basis of SCA and SCD occurring in subjects < 50 years of age in Tuscany, Italy.

Methods and results

Creation of the ToRSADE registry allowed implementation of a repository for clinical, molecular and genetic data. For 22 patients, in whom a genetic substrate was documented or suspected, blood samples could be analyzed; 14 were collected at autopsy and 8 from resuscitated patients after SCA. Next genera

SUBMITTER: Girolami F 

PROVIDER: S-EPMC9795053 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature