Preparation, biological characterization and preliminary human imaging studies of ⁶⁸Ga-DOTA-IBA.

ABSTRACT:

Purpose

In this study, DOTA-IBA was radiolabeled with ⁶⁸Ga and we determined the optimum labelling conditions and assessed the biological properties of ⁶⁸Ga-DOTA-IBA. We investigated the biodistribution of ⁶⁸Ga-DOTA-IBA in normal animals and undertook PET/CT imaging in humans. Finally, we explored the feasibility ⁶⁸Ga-DOTA-IBA as a bone imaging agent and demonstrated its potential for the therapeutic release of ¹⁷⁷Lu/²²⁵Ac-DOTA-IBA.

Methods

The controlled variables method was used to assess the impact of variables on the radiochemical purity of ⁶⁸Ga-DOTA-IBA. The biological properties of ⁶⁸Ga-DOTA-IBA were investigated.⁶⁸Ga-DOTA-IBA micro-PET/CT imaging was performed on animals

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9795169 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature