The emerging role of regulatory cell-based therapy in autoimmune disease.

ABSTRACT: Autoimmune disease, caused by unwanted immune responses to self-antigens, affects millions of people each year and poses a great social and economic burden to individuals and communities. In the course of autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes mellitus, and multiple sclerosis, disturbances in the balance between the immune response against harmful agents and tolerance towards self-antigens lead to an immune response against self-tissues. In recent years, various regulatory immune cells have been identified. Disruptions in the quality, quantity, and function of these cells have been implicated in autoimmune disease development. Therefore, targeting or engineering these cells is a promising therapeutic for different autoimmune dise

SUBMITTER: Ghobadinezhad F 

PROVIDER: S-EPMC9795194 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature