Baseline data of a sequential multiple assignment randomized trial (STEP study).

ABSTRACT:

Aim

Research has shown that preventative intervention in individuals at ultra-high risk of psychosis (UHR) improves symptomatic and functional outcomes. The staged treatment in early psychosis (STEP) trial aims to determine the most effective type, timing and sequence of interventions in the UHR population by sequentially studying the effectiveness of (1) support and problem solving, (2) cognitive-behavioural case management and (3) antidepressant medication with an embedded fast-fail option of (4) omega-3 fatty acids or low-dose antipsychotic medication. This paper presents the recruitment flow and baseline clinical characteristics of the sample.

Methods

STEP is a sequential multiple assignment randomized trial. We present the baseline demographics, clinical characteristics

SUBMITTER: Hartmann JA 

PROVIDER: S-EPMC9795376 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature