Progesterone Receptor-Mediated Regulation of Cellular Glucose and ¹⁸F-Fluorodeoxyglucose Uptake in Breast Cancer.

ABSTRACT:

Context

Positron emission tomography imaging with 2-deoxy-2-[¹⁸F]-fluoro-D-glucose (FDG) is used clinically for initial staging, restaging, and assessing therapy response in breast cancer. Tumor FDG uptake in steroid hormone receptor-positive breast cancer and physiologic FDG uptake in normal breast tissue can be affected by hormonal factors such as menstrual cycle phase, menopausal status, and hormone replacement therapy.

Objective

The purpose of this study was to determine the role of the progesterone receptor (PR) in regulating glucose and FDG uptake in breast cancer cells.

Methods and results

PR-positive T47D breast cancer cells treated with PR agonists had increased FDG uptake compared with ethanol control. There was no significant change in FDG uptake

SUBMITTER: Salem K 

PROVIDER: S-EPMC9795483 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature