Differential effects of bariatric surgery and lifestyle interventions on plasma levels of Lp(a) and fatty acids.

ABSTRACT:

Background

Limited evidence suggests that surgical and non-surgical obesity treatment differentially influence plasma Lipoprotein (a) [Lp(a)] levels. Further, a novel association between plasma arachidonic acid and Lp(a) has recently been shown, suggesting that fatty acids are a possible target to influence Lp(a). Here, the effects of bariatric surgery and lifestyle interventions on plasma levels of Lp(a) were compared, and it was examined whether the effects were mediated by changes in plasma fatty acid (FA) levels.

Methods

The study includes two independent trials of patients with overweight or obesity. Trial 1: Two-armed intervention study including 82 patients who underwent a 7-week low energy diet (LED), followed by Roux-en-Y gastric bypass and 52-week follow-up (surger

SUBMITTER: Berk KA 

PROVIDER: S-EPMC9795629 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature