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Structure and function of aldopentose catabolism enzymes involved in oxidative non-phosphorylative pathways.

ABSTRACT: Platform chemicals and polymer precursors can be produced via enzymatic pathways starting from lignocellulosic waste materials. The hemicellulose fraction of lignocellulose contains aldopentose sugars, such as D-xylose and L-arabinose, which can be enzymatically converted into various biobased products by microbial non-phosphorylated oxidative pathways. The Weimberg and Dahms pathways convert pentose sugars into α-ketoglutarate, or pyruvate and glycolaldehyde, respectively, which then serve as precursors for further conversion into a wide range of industrial products. In this review, we summarize the known three-dimensional structures of the enzymes involved in oxidative non-phosphorylative pathways of pentose catabolism. Key structural features and reaction mechanisms of a diverse set of enzymes responsible for the catalytic steps in the reactions are analysed and discussed.

SUBMITTER: Ren Y

PROVIDER: S-EPMC9795676 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Structure and function of aldopentose catabolism enzymes involved in oxidative non-phosphorylative pathways.

Ren Yaxin Y Eronen Veikko V Blomster Andberg Martina M Koivula Anu A Hakulinen Nina N

Biotechnology for biofuels and bioproducts 20221228 1

Platform chemicals and polymer precursors can be produced via enzymatic pathways starting from lignocellulosic waste materials. The hemicellulose fraction of lignocellulose contains aldopentose sugars, such as D-xylose and L-arabinose, which can be enzymatically converted into various biobased products by microbial non-phosphorylated oxidative pathways. The Weimberg and Dahms pathways convert pentose sugars into α-ketoglutarate, or pyruvate and glycolaldehyde, respectively, which then serve as p ...[more]

PMID: 36578086

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Dataset Information

Structure and function of aldopentose catabolism enzymes involved in oxidative non-phosphorylative pathways.

Publications

Structure and function of aldopentose catabolism enzymes involved in oxidative non-phosphorylative pathways.

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