Peer victimization, depression, and non-suicidal self-injury among Chinese adolescents: the moderating role of the 5-HTR2A gene rs6313 polymorphism.

ABSTRACT:

Background

Peer victimization is a crucial risk predictor for adolescent non-suicidal self-injury (NSSI). However, adolescent NSSI reactions to peer victimization exhibit large individual differences. This study explored whether depression mediated the association between peer victimization and adolescent NSSI, and whether this mediating path was moderated by the 5-HTR2A gene rs6313 polymorphism.

Methods

A total of 667 adolescents (Mean_age = 12.81, SD = 0.48) completed questionnaires regarding peer victimization, depression, and NSSI. Genomic DNA was extracted from saliva and buccal cells from each participant.

Results

The results showed that the positive relation between peer victimization and adolescent NSSI was mediated by depression. Moreover, the tripl

SUBMITTER: Li M 

PROVIDER: S-EPMC9795745 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature