Circulating miR-320a-3p and miR-483-5p level associated with pharmacokinetic-pharmacodynamic profiles of rivaroxaban.

ABSTRACT:

Background

Novel biomarkers for personalizing anticoagulation remain undetermined. We aimed to investigate the association of plasma miRNAs with pharmacokinetic-pharmacodynamic (PK-PD) profiles of rivaroxaban.

Methods

This is a multicenter, exploratory study of miRNAs in a Chinese population. Healthy volunteers and patients receiving rivaroxaban were enrolled in the study. The area under the plasma concentration-time curve from time 0-t h (AUC_0-t) and anti-Xa activity at 3 h (AXA_3h) were measured in healthy volunteers, and AXA_3h was measured in patients. MiRNAs were detected by miRNA microarray in 26 healthy volunteers with 20 mg rivaroxaban, and quantitative reverse transcription polymerase chain reaction was used to exclude undetectable one

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9795792 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature