Optimal dosing of enoxaparin in overweight and obese children.

ABSTRACT:

Aim

Current enoxaparin dosing guidelines in children are based on total body weight. This is potentially inappropriate in obese children as it may overestimate the drug clearance. Current evidence suggests that obese children may require lower initial doses of enoxaparin, therefore the aim of this work was to characterise the pharmacokinetics of enoxaparin in obese children and to propose a more appropriate dosing regimen.

Methods

Data from 196 unique encounters of 160 children who received enoxaparin treatment doses were analysed. Enoxaparin concentration was quantified using the chromogenic anti factor Xa (anti-Xa) assay. Patients provided a total of 552 anti-Xa samples. Existing published pharmacokinetic (PK) models were fitted and evaluated against our dataset using pred

SUBMITTER: Derbalah A 

PROVIDER: S-EPMC9795990 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature