The COLO-COHORT (Colorectal Cancer Cohort) study: Protocol for a multi-centre, observational research study and development of a consent-for-contact research platform.

ABSTRACT:

Aim

The COLO-COHORT study aims to produce a multi-factorial risk prediction model for colorectal neoplasia that can be used to target colonoscopy to those at greatest risk of colorectal neoplasia, ensuring that people are not investigated unnecessarily and maximizing the use of limited endoscopy resources. The study will also explore the link between neoplasia and the human gut microbiome. Additionally, the study aims to generate a cohort of colonoscopy patients who are 'research ready' through the development of a consent-for-contact (C4C) platform, to facilitate a range of colorectal cancer prevention studies to be conducted at scale and speed.

Methods and analysis

This is a multi-centre observational study involving sites across the UK. Recruitment is over a 6-year period

SUBMITTER: Hampton JS 

PROVIDER: S-EPMC9796014 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature