Rat liver ECM incorporated into electrospun polycaprolactone scaffolds as a platform for hepatocyte culture.

ABSTRACT: Liver disease is expanding across the globe; however, health-care systems still lack approved pharmaceutical treatment strategies to mitigate potential liver failures. Organ transplantation is the only treatment for liver failure and with increasing cases of liver disease, transplant programs increasingly cannot provide timely transplant availability for all patients. The development of pharmaceutical mitigation strategies is clearly necessary and methods to improve drug development processes are considered vital for this purpose. Herein, we present a methodology for incorporating whole organ decellularised rat liver ECM (rLECM) into polycaprolactone (PCL) electrospun scaffolds with the aim of producing biologically relevant liver tissue models. rLECM PCL scaffolds have been produced with

SUBMITTER: Bate TSR 

PROVIDER: S-EPMC9796056 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature