A core outcome domain set for clinical research on capillary malformations (the COSCAM project): an e-Delphi process and consensus meeting.

ABSTRACT:

Background

There is limited evidence on the best available treatment options for capillary malformations (CMs), mainly due to the absence of uniform outcome measures in trials on therapies. A core outcome set (COS) enables standard reporting of trial outcomes, which facilitates comparison of treatment results.

Objectives

To develop a core outcome domain set (CDS), as part of a core outcome set (COS), for clinical research on CMs.

Methods

Sixty-seven potentially relevant outcome subdomains were recognized based on the literature, focus group sessions, and input from the COSCAM working group. These outcome subdomains were presented in an online Delphi study to CM experts (medical specialists and authors of relevant literature) and (parents of) patients with CM (internat

SUBMITTER: Langbroek GB 

PROVIDER: S-EPMC9796083 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature