Cervical intraepithelial neoplasia in women with transformation zone type 3: cervical biopsy versus large loop excision.

ABSTRACT:

Objective

To compare the proportion of cervical intraepithelial neoplasia grade 2 or higher (CIN2+) in cervical biopsies with that in large loop excision of the transformation zone (LLETZ) specimens in women aged ≥45 years with transformation zone type 3 (TZ3).

Design

Multicentre cross-sectional study.

Setting

Three colposcopy clinics in the Central Denmark Region.

Population

Women aged ≥45 years referred to colposcopy as a result of a positive human papillomavirus (HPV) test and/or abnormal cytology and with TZ3 at colposcopy.

Methods

Women had multiple biopsies taken and an LLETZ was performed.

Main outcome measures

Histologically confirmed CIN2+ in biopsies compared with that in LLETZ specimens.

Results

Of 166 eligible women at colposcop

SUBMITTER: Gustafson LW 

PROVIDER: S-EPMC9796102 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature