Switches between biologics in patients with moderate-to-severe psoriasis: results from the French cohort PSOBIOTEQ.

ABSTRACT:

Background

Biologics are the cornerstone of treatment of patients with moderate-to-severe plaque psoriasis and switches between biologics are frequently needed to maintain clinical improvement over time.

Objectives

The main purpose of this study was to describe precisely switches between biologics and how their pattern changed over time with the recent availability of new biologic agents.

Methods

We included patients receiving a first biologic agent in the Psobioteq multicenter cohort of adults with moderate-to-severe psoriasis receiving systemic treatment. We described switches between biologics with chronograms, Sankey and Sunburst diagrams, assessed cumulative incidence of first switch by competing risks survival analysis and reasons for switching. We assessed the

SUBMITTER: Curmin R 

PROVIDER: S-EPMC9796114 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature