Prolongation of cortical sleep spindles during hippocampal interictal epileptiform discharges in epilepsy patients.

ABSTRACT:

Objective

Memory deficits are frequent among patients with epilepsies affecting the temporal lobe. Hippocampal interictal epileptic discharges (hIEDs), the presumed epileptic exaggeration of sharp wave-ripples (SWRs), are known to contribute to memory dysfunction, but the potential underlying mechanism is unknown. The precise temporal coordination between hippocampal SWRs and corticothalamic spindles during sleep is critical for memory consolidation. Moreover, previous investigation indicated that hIEDs induce neocortical spindlelike oscillation. In the present study, we aimed to assess the influence of hIEDs on neocortical spindles.

Methods

We analyzed the spindle characteristics (duration, amplitude, frequency) of 21 epilepsy patients implanted with foramen ovale (FO) elec

SUBMITTER: Sakovics A 

PROVIDER: S-EPMC9796153 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature