Successful Treatment of Balamuthia mandrillaris Granulomatous Amebic Encephalitis with Nitroxoline.

ABSTRACT: A patient in California, USA, with rare and usually fatal Balamuthia mandrillaris granulomatous amebic encephalitis survived after receiving treatment with a regimen that included the repurposed drug nitroxoline. Nitroxoline, which is a quinolone typically used to treat urinary tract infections, was identified in a screen for drugs with amebicidal activity against Balamuthia.

SUBMITTER: Spottiswoode N 

PROVIDER: S-EPMC9796214 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature